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Identification of a Molecularly-Defined Subset of Breast and Ovarian ...These studies support the use of PARPi-ATRi for the treatment of ovarian cancers that progress on PARPi in the clinic. Results. Genomic instability and ... Role of Biomarkers in the Development of PARP InhibitorsLe traitement de maintenance par PARPi après réponse au platine en rechute sensible a été étudié dans 4 essais randomisés contrô- lés vs placebo, réalisés dans ... Expanding the Perspective on PARP1 and Its Inhibitors in Cancer ...We assessed the effects of the PARPi. Olaparib on cell viability, homologous recombination, and DNA repair. We assessed underlying. Epigenetic and Genomic Hallmarks of PARP-Inhibitor Resistance in ...Abstract. Poly(ADP-ribose) polymerases (PARP) are enzymes involved in DNA-damage repair. Inhibition of PARPs is a promising strategy for targeting cancers ... PARP1 Inhibition Radiosensitizes Models of Inflammatory Breast ...We report here analysis of outcome of PARPi treatment in patients including those with platinum resistant disease. Methods: In this study, we analyzed efficacy ... Combining PARP with ATR inhibition overcomes PARP inhibitor and ...PARPi are an area of active clinical investigation in oncology as they (1) exploit synthetic lethality in tumours with defective homologous recombination (HR) ... Prise en charge médicale de la récidive du cancer épithélial de l ...Abstract: Poly (ADP-ribose) polymerase (PARP) inhibitors (PARPi) induce cytotoxic effects as single agents in tumors characterized by defective ... SETD1A-dependent EME1 transcription drives PARPi sensitivity in ...PARPi have been largely adopted in triple-negative metastatic breast cancer, but their place has been less clearly defined in endocrine-receptor ... The role of PARP in DNA repair and its therapeutic exploitationPARPi. In malignant cells with integral DDR mechanisms,. PARPi could be used in combination with DNA-damaging agents to increase radiosensitivity ... Role of PARP Inhibitors in Cancer Immunotherapy: Potential Friends ...PARPi treatment which directly cleaves GSDME and, subsequently induces pyroptosis. PARP Inhibitors: A Major Therapeutic Option in Endocrine-Receptor ...Poly(ADP-ribose) polymerase. (PARP) inhibitor (PARPi) is a DNA repair enzyme associated with DNA damage repair. PARPi takes PARP as a target to ... (12)??????(A) - Googleapis.com????????????????????????????. ???????????????1?2????????????. ??????????? ...
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