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ABSTRACT: The bicyclic boronate VNRX-5133 (taniborbactam) is a new type of ?-lactamase inhibitor in clinical development.
Bicyclic Boronate VNRX-5133 Inhibits Metallo- and Serine-?Abstract: ?-Lactam antibiotics are the most widely prescribed antibacterial drugs due to their low toxicity and broad spectrum. biomolecules - CONICET?-Lactamases enable resistance to almost all ?-lactam antibiotics. Pioneering work revealed that acyclic boronic acids can act as 'transition state ... Structural basis of metallo-?-lactamase, serine-?-lactamase and ...Essayez avec l'orthographe
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