JP WO2016/063991 A1 2016.4.28 10 (57)???? ??????? ...

?????????????????????. ??????????pH???????4?. ?????????pH8?0?9?5??????. ????pH?????????? ...







BALB/c ( 1 ?2 Ie(11?2') ? C56BL/6 ?2b) - ?????????????
... TD?2.0???????????????????. ??????????? ... ???????(EC 3.4.21.1). ?????????. (?????? ...
???????????? ?????????? - CareCure-MD
... ?????????????. ???????????????????????. ????????????????? ?) ???????K?????. ???????? ...
2.5 ?????????? - MLN9708 - PMDA
????????????????. ???????? P36T ???????? ... Rahbar, T.D. Lee, J.A. Baker, L.T. Rabinowitz, Y. Asmerom, K. Legesse, H.M. ...
Title Author(s) Citation Issue Date Doc URL Type File Information
?VTD?31??TD?11??. VTD????????p?. 0.0001??2????PFS? ... ?????????????????????????????????????? ...
?????????? - TMS???
SDS??????????5J??50?H?????????0?5??. ???????????30??30????????????????. ?SDS?PAGE?12?gel???????
????????????????????? ???????
?????????????????????????????????. ??? ... Holsapple M, Ladics GS, Landry TD, MacIntosh SC, Rice EA, Privalle LS, Steiner HY,.
23656525 ??????? - KAKEN
???????????????????????????????AD ????????. ????????????????? 19,20?????? KLK7 ???????? ...
??????7??????????1,4-?????
????????????????????????????? 20S ?????????????????. ????????? Page 37. ?????????????. ?30 ...
??????
TD, thalidomide + dexamethasone; D, dexamethasone; MP, melphalan; MPT ... ??????????????????????????. ????????? 24 ...
? ? 1 ? ???????????ACT????????????
(57)????. ????? ? ? 1 ? ???????????ACT?????????????????. ?????????????????????ACT?????????? ...
?? 6 ?? ???????????????????????
???????(CHT)??????????????????????????CHT??. ?????????????????????????????????????? ...
?????????????????????????? S
??????????????????????????. ???? '??????H tors. Ch. sinCh mO. nIhibi. 11W h td. gGemi ll i. S r. P try i urn y ea ange i.