Guidelines for the management of asthma in adults - TAC
Diverted arachidronate to this pathway after inhibition of COX by NSAIDs causes increased formation of leukotrienes, which are also mediators of inflammation.1.
COX-2 ???? ????? ?? ???? ?????? 1????? ???? ????? ??? ?? ????. ? NSAIDs? ??????? ??? ?? ???? ?. ?? COX-2 ???? celecoxib?? ????? ??. ?? ... ??? ???? - ???????????-?? ??(??? ???(eosinophilic phenotype) ?? ?. ? ?? ????????? ??? ??? ?? ?? ?? ??). ????? ??? ?? ?? ? ... ?? ??????? ???? ?? ?? ????? ?? ??, ??, ??? ??/??. ?? ???. ?? ??? ???? ??, ??, ???? ?? ??. ? ???? ... ??????? ???(NSAIDs) ??? ?? ??? ??? ???? ibuprofen ???? ??? ???. ??? ???? ?? ?????. ????, ??, ??. ???? ?? ??? ?? ???? ?????? ?. ??????????????????????? ?????????????????????????GB/T 51366 ???? 2.????????????????????GB/T 51366 ???????????? ... ?????????????1 ???????????????????????????????????. ????????????HRB400 ??????????????????????. ??HPB300 ... ??????????10G409??. ?????????????????????????????????. ????????????????????????????????? ... ??????????????2019 ???? ???EU-01-01 ???????; ?. EU-01-02 ?????????. ??????????????????????????????????. ?????????????? ... ??????????????????????????????????????. ??????????????????????????fb=3.6HB?????. ????????????????GB/T1172?1999 ... ???????????????????????????. ?????????????????????????????????. ????????????????????????????????. ????????????????1??????????????????????. ??????????????????????????. ?????CECS?????????????CABEE???. ????? ... ????????????????2022??[?!?] ??????????????????????????????????????18Zg8Z??. ????????????????????????????
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