DECIPHERING THE MECHANISMS OF WT1 GLOMERULOPATHY
Nephron Progenitor Cells; PTA: Pre-tubular Aggregates; RV: Renal Vesicles; MET: Mesenchymal-to-Epithelial Transition; PT: Proximal Tubule.
New Insights into the Regulated Differentiation of Intercalated Cells ...La maladie rénale chronique est définie indépendamment de sa cause, par la présence, pendant plus de 3 mois, de marqueurs d'atteinte rénale ou d'une baisse ... The crucial roles played by HNF1? during kidney developmentRe-analysis of these mutants shows that this 'pre-tubular aggregate-like state' is transient, and by E15.5, NPCs lose Six2 expression as well as expression of ... Notch Signaling in Kidney Development, Maintenance, and DiseaseHigh Six2 levels were observed in NPCs and Six2 was pre- sent at lower levels in anatomically distinct pretubular aggregates. (Figure 2B), whereas Cited1 was ... Modelling of Cell Movements and Aggregations During Early ...At the molec- ular level, recent observations identified nearly 100 genes with polarized P/D expression within the pretubular aggregate. (Mugford et al ... Development of human induced pluripotent stem cell derived kidney ...Nephron progenitor cells (NPCs) self-renew and differentiate into nephrons, the functional units of the kidney. Conserved and Divergent Features of Mesenchymal Progenitor Cell ...pre-tubular aggregates (PTA), which develop sequentially into renal vesicles (RV), comma-shaped body (CSB) and. S-shaped body (SSB) ... Branching Morphogenesis and Nephron Segmentation in Kidney ...La maladie rénale chronique est définie indépendamment de sa cause, par la présence, pendant plus de 3 mois, de marqueurs d'atteinte rénale ... Regulation of RNA expression in nephron progenitor cellsthat are often found within the pretubular aggregate (Figure S3g). ... pre, distal tubule precursor; PT, proximal tubule; DT, distal. 1404. Déterminants moléculaires et cellulaires des maladies rénales ...On the other hand, the intermediate stages that are anatomically described as renal vesicles, pre-tubular aggregates, and comma- and s-shaped bodies were not ... Single-Cell multiomics reveals ENL mutation perturbs kidney ...We find widespread evidence for deficiencies in this pathway in LPD kidneys, including reduced Wnt4 expression in advanced pretubular aggregate/ ... the impact of low protein diet on the developing kidney - bioRxivPrior to epithelialisation, nephron progenitors coalesce to form a pretubular aggregate (PTA), which is characterised as a cluster of cells ... Nephron progenitor commitment is a stochastic process influenced ...Recurrent gain-of-function mutations in the histone reader protein ENL have been identified in Wilms tumor, the most prevalent pediatric ...
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