insights from evolutionary biology and population genetics - Hal Inrae
Studies using indirect genetic methods to reconstruct invasion routes have suggested that admixtures between different source populations often ...
In vivo analysis of demyelination and remyelination in an animal ...In contrast, Chrm1 null EAE mice displayed a moderately reduced disease severity from the earliest stages of disease, followed by a remission ... CPT1A plays a key role in the development and treatment of multiple ...Refining studies using animal models could serve as a key strategy to enhance the translation of research findings to clinical stages [4]. Tonabersat Significantly Reduces Disease Progression in an ...The EAE mice were perfused at maximum EAE clinical severity with clinical scores of 3-3.5 (14-16 days post-immunization). Brains were extracted and post-fixed ... IC100: a novel anti-ASC monoclonal antibody improves functional ...Statistical analysis was performed using the 2-tailed Fisher exact probability test for incidence and the Wilcoxon rank sum test for clinical. SIMOA as Emerging Technology in EAEConclusions: Diverse EAE models bearing genetic, clinical and histopathological heterogeneity, show different profiles of sensory and ... Assessment of Mitochondrial Dysfunction in Experimental ...Existing literature support the concept that an exercise regimen can reduce the severity of some of the clinical manifestations of EAE,. Original Article - Intermittent Feeding Attenuates Clinical Course of ...Collectively, these results establish NLRP12 as a negative regulator of T cell activation in models of antigen immunization and DSS-induced colitis. NLRP12- ... Treatment of experimental autoimmune encephalomyelitis in rat by 1 ...These findings not only validate our gene expression data, but also underscore the importance of the rat EAE model in translational medicine. ... with ... Accelerated remyelination during inflammatory demyelination ... - eLifeEAE mice treated with miR-146a mimic once a week for 6 weeks initiated on day 14 p.i. had significantly decreased cumulative clinical score ... Technical Assessment of Motor and Behavioral Tests in Rodent ...A study in the EAE model suggested that neuroinflammation destabilizes synapses(Yang et al., 2013). Short dendritic segments were in vivo two- ... Instability of excitatory synapses in experimental autoimmune ...Animals of the placebo-treated EAE group exhibited high clinical scores evidencing the appearance and progression of the disorder, whereas the animals ... Generation of a murine model of chronic progressive experimental ...A two-way ANOVA test was applied to analyze the significance of EAE clinical scores. Student's t-test was used to assess other analyses, and ...
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