CCNE1 amplification is synthetic-lethal with PKMYT1 kinase inhibition
Activating mutations and translocations of the FGFR3 gene are commonly seen in urothelial cell carcinoma (UCC) of the bladder and urinary ...
HGF/MET Signalling and DNA Damage Response - Scientific ArchivesOur synthetic lethality screen revealed enhanced sensitivity of DDX11 mutant cells for reduced protein expression of different subunits of ... Chapter 5 Identi ication of lethal microRNAs ... - Amsterdam UMCA synthetic lethal therapeutic approach: Poly(ADP) ribose polymerase inhibitors for the treatment of cancers deficient in DNA double-strand break repair. J ... Synthetic lethality of the ALDH3A1 inhibitor dyclonine and xCT ...A Synthetic Lethal Screen Identifies DNA Repair Path- ways that Sensitize Cancer Cells to Combined ATR Inhibition and Cisplatin Treatments. PLoS ONE. 2015 ... Defective sister chromatid cohesion is synthetically lethal ... - SciSpaceWe present a proteogenomic study of 108 human papilloma virus (HPV)-negative head and neck squamous cell carcinomas (HNSCCs). DNA Damage Response Mechanisms in Head and Neck Cancera highly increased risk for SCC of the head and neck (HNSCC), hematopoietic malignancies, and ... Figure 27: Testing for synthetic lethal or viable interaction ... Chapter_4.pdf - the University of Groningen research portalDEAD/H-box helicases are implicated in virtually every aspect of RNA metabolism, including transcription, pre-mRNA splicing, ribosomes. Discovery of synthetic lethal or viable interactions between DNA ...Les Cancers Epidermoïdes de la Tête et du Cou (CETC) représentent les septièmes tumeurs les plus fréquentes au niveau mondial en 2020. Biomarqueurs du microenvironnement tumoral pour la stratification ...Although the synthetic lethality screen was only performed in HNSCC cells, the highlighted functions of PD-L1 may be similar across cell types. Caracterización del fenotipo de semi- dependencia a antibióticos ...La clasificación de Ambler distingue cuatro clases de ?-lactamasas (A, B, C y D), en función de sus secuencias aminoacídicas y su perfil hidrolítico: las de las ... Resúmenes SIIC - SiicsaludLos fármacos implicados con mayor frecuencia son los antibióticos betalactámicos (BL), especialmente amoxicilina, seguidos de los ... TESIS DOCTORAL - DIGIBUG PrincipalInteresantemente, otra clasi- ficación es sólo de carácter farmacocinético, de acuerdo al tiempo de vida media, y aplicada fundamentalmente a las cefalosporinas ... Rotación de antibióticos: una estrategia para paliar la resistenciaLos antimicrobianos conforman un gran grupo de compuestos de ... Td o Tdap, según la edad (capítulo 19). 3. La enfermedad no confiere ...
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