Université du Québec à Montréal - Archipel UQAM
Since then, the first CECR2 chemical probes have been developed and disclosed. Collaborative work between Novartis and the SGC has led to the development of NVS ...
Advancements in the Development of non-BET Bromodomain ...TP-238 is a CECR2 binder (KD = 10 nM), also active on BPTF and BRD9 with KD = 120nM and 1.1 ?M, respectively, (Ycas et al., 2020). GSK4027 binds to the. PCAF ... Reevaluation of bromodomain ligands targeting BAZ2ATP-238 was reported as a CECR2/BPTF chemical probe by Takeda and the Structural Genomics Consortium (SGC), with 12-fold higher selectivity for CECR2 (Kd = 10 nM) ... The Optimisation of Potent ATAD2 and CECR2 Bromodomain ...The ATAD2 and CECR2 bromodomains are exciting targets for drug discovery and, consequently, inhibitors for both bromodomains are starting to appear in the ...
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