Ubiquitination modulates a protein energy landscape site ... - bioRxiv
Trafficking of multiple proteins is controlled reversibly by ubiquitin and/or SUMO directly or indirectly via regulation of transport machinery components.
Mechanism of ubiquitin ligation and lysine prioritization by a HECT E3Lysosomal degradation of ubiquitinated TM-proteins typically involves their transport to endosomes, followed by the formation of so-called multi ... Site-specific ubiquitination affects protein energetics ... - eScholarshipFirst, the ubiquitin-activating enzyme, or E1, forms a high energy thiol ester bond with ubiquitin in an ATP-dependent reaction. The next step is transfer of ... Role of Ubiquitin and SUMO in Intracellular TraffickingRegulation of ubiquitin-binding domains?? By contrast, the UBA domain in the full-length P47 protein binds to ubiquitin more effectively when p47 is associated ...
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