The crucial roles played by HNF1? during kidney development
Re-analysis of these mutants shows that this 'pre-tubular aggregate-like state' is transient, and by E15.5, NPCs lose Six2 expression as well as expression of ...
Notch Signaling in Kidney Development, Maintenance, and DiseaseHigh Six2 levels were observed in NPCs and Six2 was pre- sent at lower levels in anatomically distinct pretubular aggregates. (Figure 2B), whereas Cited1 was ... Modelling of Cell Movements and Aggregations During Early ...At the molec- ular level, recent observations identified nearly 100 genes with polarized P/D expression within the pretubular aggregate. (Mugford et al ... Development of human induced pluripotent stem cell derived kidney ...Nephron progenitor cells (NPCs) self-renew and differentiate into nephrons, the functional units of the kidney.
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