Role of Biomarkers in the Development of PARP Inhibitors
Le traitement de maintenance par PARPi après réponse au platine en rechute sensible a été étudié dans 4 essais randomisés contrô- lés vs placebo, réalisés dans ...
Expanding the Perspective on PARP1 and Its Inhibitors in Cancer ...We assessed the effects of the PARPi. Olaparib on cell viability, homologous recombination, and DNA repair. We assessed underlying. Epigenetic and Genomic Hallmarks of PARP-Inhibitor Resistance in ...Abstract. Poly(ADP-ribose) polymerases (PARP) are enzymes involved in DNA-damage repair. Inhibition of PARPs is a promising strategy for targeting cancers ... PARP1 Inhibition Radiosensitizes Models of Inflammatory Breast ...We report here analysis of outcome of PARPi treatment in patients including those with platinum resistant disease. Methods: In this study, we analyzed efficacy ...
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