Resistance of Ferroportin to Hepcidin Binding causes Exocrine ...
Thus, the hepcidin-ferroportin axis must be tightly regulated to maintain serum iron levels. Hepcidin is a peptide of 25 amino acids and is ...
Mechanism of Ca2+ transport by ferroportin - eLifeHepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science. 2004 Dec 17;306(5704):2090?3. 6. Structural basis of ferroportin inhibition by minihepcidin PR73Synthetic hepcidin triggered hypoferremia in control but not iron-loaded wt animals. 29. Furthermore, it dramatically decreased hepatic and ... Molecular model of the ferroportin intracellular gate and implications ...Our data uncovered a crosstalk between hepcidin and the IRE/IRP system that controls ferroportin expression in the liver and spleen, and thereby ...
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