Replication Stress, DNA Damage, Inflammatory Cytokines ... - HAL
Formation of cytoplasmic inclusions (CIs) of TDP-43 and FUS, along with DNA damage accumulation, is a hallmark of affected motor neurons in ...
Mechanisms of DNA damage, repair and mutagenesis - COREThese DNA lesions/adducts arise from a vari- ety of endogenous and exogenous sources, including chemical mutagens, UV radiation, reactive oxygen ... 1 DNA damage response defects induced by the formation of TDP ...Endogenous metabolites and exogenous agents such as UV light induce a variety of chemical alterations in the primary structure of DNA. These ... Compartmentalization of the DNA damage response - IghSources and Consequences of DNA Damage. DNA damage can be induced by exogenous physical agents, by endogenous chemical genotoxic agents that ...
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