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CCNE1 amplification is synthetic-lethal with PKMYT1 kinase inhibitionActivating mutations and translocations of the FGFR3 gene are commonly seen in urothelial cell carcinoma (UCC) of the bladder and urinary ... HGF/MET Signalling and DNA Damage Response - Scientific ArchivesOur synthetic lethality screen revealed enhanced sensitivity of DDX11 mutant cells for reduced protein expression of different subunits of ... Chapter 5 Identi ication of lethal microRNAs ... - Amsterdam UMCA synthetic lethal therapeutic approach: Poly(ADP) ribose polymerase inhibitors for the treatment of cancers deficient in DNA double-strand break repair. J ...
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