Epigenetic and Genomic Hallmarks of PARP-Inhibitor Resistance in ...
Abstract. Poly(ADP-ribose) polymerases (PARP) are enzymes involved in DNA-damage repair. Inhibition of PARPs is a promising strategy for targeting cancers ...
PARP1 Inhibition Radiosensitizes Models of Inflammatory Breast ...We report here analysis of outcome of PARPi treatment in patients including those with platinum resistant disease. Methods: In this study, we analyzed efficacy ... Combining PARP with ATR inhibition overcomes PARP inhibitor and ...PARPi are an area of active clinical investigation in oncology as they (1) exploit synthetic lethality in tumours with defective homologous recombination (HR) ... Prise en charge médicale de la récidive du cancer épithélial de l ...Abstract: Poly (ADP-ribose) polymerase (PARP) inhibitors (PARPi) induce cytotoxic effects as single agents in tumors characterized by defective ...
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