DNA damage checkpoints balance a tradeoff between diploid
Exogenous sources include ultraviolet (UV) light from the sun, ionizing radiation (IR), genotoxic chemicals, and carcinogens that are inhaled or ingested[5]. It ...
The DNA Damage Repair Response - Clinics of OncologyDDR attenuation induces EMT in epithelial normal and neoplastic cells, that can be further stimulated by exogenous DNA damage. ... Halazonetis, ... The DNA damage response - from cell biology to human diseaseAbstract: DNA lesions arise from a combination of physiological/metabolic sources and exogenous environmental influences. DNA damage in cancer development: special implications in viral ...Similar to exogenous DNA damage, inherent DNA repair defects in tumours may also increase the production of cytosolic DNA and appear to ...
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